DOSEFX Software for internal dosimetry

DoseFX is medical device software for internal dosimetry (Class I). DoseFX  calculates internal organ and tumor doses during clinical radiopharmaceutical administrations.

Used in Nuclear Medicine For Quality control Lab Management
Logo DoseFX
 

DoseFX is medical device software for internal dosimetry (Class I). DoseFX  calculates internal organ and tumor doses during clinical radiopharmaceutical administrations.

During radiometabolic treatments it’s impossible to target only the tumors, and happens that radionuclides are retained in non-target organs causing radiation doses that may result in toxicity and organ loss of efficiency. For this reason it’s essential to ensure that normal organ radiation doses are within safe range.

DOSEFX Software for internal dosimetry

DoseFX Goals

DoseFX is specifically designed to support the nuclear medicine physician during radiopharmaceutical treatment of individual patients (for internal dosimetry).
DoseFX performs dose calculation which enables the medical staff to develop an optimal radiation plan arrangement,  with the aim to spare normal tissue while applying a prescribed dose to the target tumor volume.
As requested by new European regulation concerning patient radiation exposure, internal organ dosimetry must be implemented by all Member States by 2018. DoseFX is a medical device tool ready to support the daily work of any nuclear medicine department where molecular radiotherapy protocols are in place.

How does DoseFX works?

After each radiopharmaceutical treatment session, the software is fed with individual patient and the radionuclide parameters and it calculates and reports the radiation dose received by the organs or the tumors of the patient.

The patient is injected with a radiopharmaceutical for the specific therapy. After injection, imaging is performed with the adequate timing  (specific for each therapy protocol) to determine the kinetics of the absorbed radiation in the patient’s body. The dose calculation process starts from the SPECT/CT or PET/CT scans, drawing the regions of interest (ROI), which enables the operator to quantify the ROI activity and its volume.

Performed by DOSEFX

Radiopharmaceutical kinetics reconstruction: Time Activity Curves in order to evaluate the ROI Number of Disintegration

DoseFX - Activity

 

Number of Disintegration and patient information are the input data for the final dose calculation process (organs and tumors absorbed dose and organ cross-irradiation)

The picture below gives an overview of the total process.

DoseFX - Process

The final result in using DoseFX is to know the organ/tumor doses in order to avoid to exceed the limits to OAR (Organ At Risk). Any organ/tumor can be designated at the same time as both a source and a target region. In this case, the energy deposited in the region is the self dose.

Main features

  • Register patient details
  • Register injected activity details
  • Support different radioisotopes
    Add Regions of Interest (ROI)
  • Number of Disintegration calculation (fitting) for each ROI
  • Fitting result management
    Selection of the target organs
  • Selection of a phantom (several) or sphere model
  • Calculate organ/tumor dose and cross-irradiation effects
    Generate final dose calculation report
  • Internal database of Dose Factors based on the most recent data models
  • Internal patients dose results database
  • User login/logout and user management
  • Traceability and result history

Highlights

  • Register patient details
  • Register injected activity details
  • Support different radioisotopes
    Add Regions of Interest (ROI)
  • Number of Disintegration calculation (fitting) for each ROI
  • Fitting result management
    Selection of the target organs
  • Selection of a phantom (several) or sphere model
  • Calculate organ/tumor dose and cross-irradiation effects
    Generate final dose calculation report
  • Internal database of Dose Factors based on the most recent data models
  • Internal patients dose results database
  • User login/logout and user management
  • Traceability and result history

Logging in

When DoseFx is launched a login screen is shown.

To use DoseFx logging in is required.

For the 14-day trial version use Admin as username and leave the password empty.

Patient screen

The patient screen is used to add, edit and delete patients.

It can also be used to select another patient by pressing the select patient button.

It is also the screen to enter the injected activity data and select the isotope that was injected

Regions of interest screen

The regions of interest screen is used to add regions of interest into the system for a selected patient.

Regions of interest are places where a radionuclide is injected.

This region can be an organ or a lesion. ROI’s (Regions Of Interest) are used as sources of radiation in the final calculation.

Acquisitions screen

The acquisitions screen is used to add acquisitions to the system. Acquisitions are moments in time where the number of counts in a region of interest are entered.

This data is then used to fit a curve to this data and calculate the number of disintegration’s of the isotope (the integral of the fitted curve).

To get to the acquisitions screen press the acquisitions screen button. Each acquisition time is displayed as the amount of hours relative to the first acquisition. Example: if the first acquisition is at 12 december 2016 at 15:00 and the second one is at 13 december 2016 at 14:00, the first header is 0 hours and the second one is 23 hours.

Integral

The integral is the same as the number of disintegration’s for the selected isotope.

To calculate this a curve is fitted using least squares exponential fitting with the formula: y(x)=AeBx

To see the graph of this for a specific region of interest click on the graph button at the end of the corresponding row. This will take you to the following screen:

Fill the form below to request download of  your free 7-day trial version of DoseFx Demo Software

According to Italian laws you must give us your consent to use your personal information. Please read our privacy policy.
 
 

Minimum system requirements

DoseFx requires the following specifications with regard to the computer on which the software is installed:

Component Description
Operating system Windows 7 32- or 64-bit, Windows 8 32- or 64-bit, Windows 8.1 32- or 64-bit, Windows 10 32- or 64-bit.
Extra software .NET Framework 4.5 or higher*
Display A display with a minimum resolution of 800*600 and 24-bit color
Input A standard mouse, touchpad or touchscreen
Keyboard Not required if the operating system provides an on-screen keyboard
Disk space About 10-50MB of free disk space is recommended to install the software**
* If .NET framework 4.5 is not installed the installer will try and install the latest version during installation.
** Note that the database can grow in size, this means that disk space requirements will grow depending on how much data is entered into the application

Information request / Pdf download

Fill in the form below to download the technical data sheet pdf with full details of DOSEFX – Software for internal dosimetry

Subscribe to our Newsletter

News and invitations to events and fairs directly in your mailbox