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DoseFX is medical device software for internal dosimetry (Class I). DoseFX calculates internal organ and tumor doses during clinical radiopharmaceutical administrations.
During radiometabolic treatments it’s impossible to target only the tumors, and happens that radionuclides are retained in non-target organs causing radiation doses that may result in toxicity and organ loss of efficiency. For this reason it’s essential to ensure that normal organ radiation doses are within safe range.
DoseFX is specifically designed to support the nuclear medicine physician during radiopharmaceutical treatment of individual patients (for internal dosimetry).
DoseFX performs dose calculation which enables the medical staff to develop an optimal radiation plan arrangement, with the aim to spare normal tissue while applying a prescribed dose to the target tumor volume.
As requested by new European regulation concerning patient radiation exposure, internal organ dosimetry must be implemented by all Member States by 2018. DoseFX is a medical device tool ready to support the daily work of any nuclear medicine department where molecular radiotherapy protocols are in place.
After each radiopharmaceutical treatment session, the software is fed with individual patient and the radionuclide parameters and it calculates and reports the radiation dose received by the organs or the tumors of the patient.
The patient is injected with a radiopharmaceutical for the specific therapy. After injection, imaging is performed with the adequate timing (specific for each therapy protocol) to determine the kinetics of the absorbed radiation in the patient’s body. The dose calculation process starts from the SPECT/CT or PET/CT scans, drawing the regions of interest (ROI), which enables the operator to quantify the ROI activity and its volume.
Performed by DOSEFX
Radiopharmaceutical kinetics reconstruction: Time Activity Curves in order to evaluate the ROI Number of Disintegration
Number of Disintegration and patient information are the input data for the final dose calculation process (organs and tumors absorbed dose and organ cross-irradiation)
The picture below gives an overview of the total process.
The final result in using DoseFX is to know the organ/tumor doses in order to avoid to exceed the limits to OAR (Organ At Risk). Any organ/tumor can be designated at the same time as both a source and a target region. In this case, the energy deposited in the region is the self dose.
When DoseFx is launched a login screen is shown.
To use DoseFx logging in is required.
For the 14-day trial version use Admin as username and leave the password empty.
The patient screen is used to add, edit and delete patients.
It can also be used to select another patient by pressing the select patient button.
It is also the screen to enter the injected activity data and select the isotope that was injected
The regions of interest screen is used to add regions of interest into the system for a selected patient.
Regions of interest are places where a radionuclide is injected.
This region can be an organ or a lesion. ROI’s (Regions Of Interest) are used as sources of radiation in the final calculation.
The acquisitions screen is used to add acquisitions to the system. Acquisitions are moments in time where the number of counts in a region of interest are entered.
This data is then used to fit a curve to this data and calculate the number of disintegration’s of the isotope (the integral of the fitted curve).
To get to the acquisitions screen press the acquisitions screen button. Each acquisition time is displayed as the amount of hours relative to the first acquisition. Example: if the first acquisition is at 12 december 2016 at 15:00 and the second one is at 13 december 2016 at 14:00, the first header is 0 hours and the second one is 23 hours.
The integral is the same as the number of disintegration’s for the selected isotope.
To calculate this a curve is fitted using least squares exponential fitting with the formula: y(x)=AeBx
To see the graph of this for a specific region of interest click on the graph button at the end of the corresponding row. This will take you to the following screen:
DoseFx requires the following specifications with regard to the computer on which the software is installed:
|Operating system||Windows 7 32- or 64-bit, Windows 8 32- or 64-bit, Windows 8.1 32- or 64-bit, Windows 10 32- or 64-bit.|
|Extra software||.NET Framework 4.5 or higher*|
|Display||A display with a minimum resolution of 800*600 and 24-bit color|
|Input||A standard mouse, touchpad or touchscreen|
|Keyboard||Not required if the operating system provides an on-screen keyboard|
|Disk space||About 10-50MB of free disk space is recommended to install the software**|