Improved production of I-124 with the Comecer ALCEO Halogen System for routine use

Denis Lamparter1, Bernd Hallman1, Francesca Boschi2, Mario Malinconico2, Samuel Samnick1
1
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg
2 Comecer S.p.a., Via Maestri del lavoro, 48014 Castel Bolognese, Italy

Aim

Comecer offers recently a new system (ALCEO halogen 2.0) for small scale routine production of I-124. In this work we performed optimization and validation of the production process with this new system. Special aim was the increase of the specific activity together with an significant decrease of volume. This was achieved by a new design of the evaporation unit and an optimized degrading foil.

Methods

I-124 was produced via the Te-124(p, n)I-124 reaction. The reaction was performed on a PETtrace 860 cyclotron (GE Healthcare, Uppsala, Sweden). With the used set up, beam currents up to 20 μA were possible. For this work beam currents between 10 μA and 15 μA were used.

The material for the irradiation was a mixture of 300 mg TeO2 and 15 mg Al2O3. This mixture was sintered into a shuttle for automated handling. Besides the use as a carrier, the shuttle works also as a sealing and supports the cooling of the target material during the irradiation. The Comecer ALCEO Halogen 2.0 itself consist of two different parts. The evaporation unit (EVP) and the irradiation unit (PTS) with a supporting cooling unit.

Alceo Halogen Components

Figure 1: Components of the Comecer ALCEO Halogen 2.0

The production of I-124 can be separated in three different parts:

  • Preparation of the shuttle (EVP)
  • Irradiation (PTS)
  • Overhaul of the irradiated shuttle (EVP)

Preparation of the shuttle

Before the first irradiation, the target material must be sintered into the shuttle. For this the target material is mixed with Al2O3 as a superplasticizer and then heat treated for melting and fixing it to the shuttle. Once prepared, the shuttle can be stored under room conditions, best directly in the EVP or in its Hotcell.

Irradiation

For the irradiation, the shuttle is send to the PTS and the cooling is switched on. The parameters for the bombardment, beam current and time, has to be chosen depending on the amount of activity needed. During the bombardment, the EVP can be prepared for the irradiated shuttle.

Overhaul of the irradiated shuttle

The Overhaul of the shuttle consist of two parts. First, extraction and trapping of the produced I-124 out of the target, and second, elution of the trapped I-124 into a product vessel.

Due to extract the produced I-124 the shuttle is once more heat treated. The same temperature gradient is also used for the first preparation of the shuttle. I-124 vapor is then trapped in a glass tube pre-coated with 0,05 N NaOH.

The trapped product is finally eluted with 100 μL of 0,05 N NaOH.

Timeline-I-124-Production

Figure 2: Timeline I-124 Production

Results

Six different productions were validated using the same shuttle and target material. Due to several reasons different beam currents and bombardment times were applied. Production data and results are shown in the table and the chart below.

Figure 3: Production data for I-124 left: results and irradiation parameters / right: absolute activity yield and weighted yield [MBq/μAh]

It can be shown, that the produced activity is only dependent on the capacity, measured in μAh.

During the production process there is a consumption of the target material. Different approaches was used to determine the life time of the prepared shuttle:

  • yield
  • visual
  • gravimetric
  • activation of the shuttle

Yield

The yield was stable (measured as MBq/μAh) over the performed productions (Figure 3).

Visual

Before and after the bombardment, a picture of the shuttle was taken. An additional picture was taken after the overhaul.

Gravimetric

The weight of the shuttle was measured before and after the irradiation and also after the overhaul. An average loss of weight of 0,387 mg/production was found.

Loss-of-weight-per-production

Figure 5: Loss of weight per production

Activation of the shuttle

The activity of the shuttle was measured after the overhaul. Out of this and the product activity an activation coefficient (product activity / activity of the shuttle) was calculated.

Activation Coefficient

Figure 6: Activation coefficient

Conclusion

Thanks to the optimized conditions for irradiation and extraction, I-124 could be produced in good radiochemical yields and high purity in less than 1mL extraction volume for routine applications.

Further work are currently on the way to determine the stability of the prepared shuttle and the number of possible extractions.

 

 

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