TC-99m Production
Semi-automatic line for the production of Tc-99m generators in GMP.

Semi-automatic line for the production of 99mTc generators in GMP.

  • Number of working chambers:
    • 12
  • Type of process:
    • Terminal sterilization
  • Type of shielding:
    • Lead 150mm / Lead 100mm
  • Automation systems available:
    • Automatic 99Mo formulation
    • Automatic filling of generator columns
    • Automatic washing of generator columns
  • Particularly interesting features:
    • Automatic in-line QC for 99Mo breakthrough during filling
  • Productivity:
    • 250 generators in 12h, 3 batch per week.

The plant allows the loading from B(U) of the 99Mo bulk, the formulation and adjustment of the chemical parameters of the solution, the loading of the 99Mo in the generator column, the autoclave sterilization of the columns, the semi-automatic assembly and the 100% QC verification of each generator. The line is therefore equipped with a series of progressive-shielding chambers able to keep safe all the plant interlocking operations, from the high-activity bulk loading to the final washing and QC operations. The double pass-through autoclave allows a transfer of the loaded columns with a one-way transfer of the material for an optimal process flow and the possibility to guarantee the productive reliability also in case of maintenance of one of the two autoclaves.

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