LETHO Automatic Compact Injector

Letho is a compact radiopharmaceutical injector system for the automatic intravenous infusion of radio drugs or radio tracers. The system allows for the infusion of gamma and beta-emitting molecules in a radiologically safe manner and with maximum control of all critical parametres such as the flow, the amount and the injection time.

LETHO - Automatic Compact Injector

Advantages and Highlights

  • can be connected to a gravity infusion system and, without changing disposables, to an automated system
  • can be washed and decontaminated with saline without “aspiration” procedures and thus never violating the essential rule of the one-way-fluid-movement for infusion pumps
  • eliminates the residue of the drug not injected
  • the extremely compact design reduces the shielding necessary for the reduction of ionising radiation in case of a radioactive fluid
  • features pure tungsten shielding in the case of gamma-emitting molecules or plastic and tungsten shielding in the case of beta emitters
  • is guaranteed for any type of radio molecule currently in clinical and pre-clinical use.

The device was created from a collaboration between Comecer and Codan Argus, a leading Swiss company in hospital infusion pumps for traditional medication and chemotherapy.
The technology and know-how of Comecer are associated with a particular infusion pump system (Argus 717V), among the most common and popular of these applications.

The Letho system works in two ways:

  • without the infusion pump, using the force of gravity
  • with the infusion pump, for maximum automation of the process

At the heart of the device there is a particular cartridge equipped with a double pierceable septum (one for each end).  This cartridge is filled using traditional dispensing systems and Comecer fractionators (Febo, Clio, Althea or others) like a normal syringe. A patent application (BO2013A000256) has been filed for the cartridge and the entire system, including the holder (the shielded container that houses the cartridge) and the infuser.

Doube Septum Cartridge with Tungsten Shielded containerDoube Septum Cartridge with Tungsten Shielded container

Certified Medical Devices

The Letho system is composed of devices that are individually certified as:

  • Letho: Class I medical device
  • cartridge: class IIA medical device
  • disposable kits: class IIA medical device
  • infusion pump: class IIB medical device

Main Innovative Features of the Letho Cartridge:

  • allows for the safe transport of a beta/gamma-emitting radio drug or radio tracer, without any loss
  • minimises shielding and the weight of the holder thanks to its compact size
  • made of plastic material suitable for the containment of injectable radio drugs
  • sterilised with ethylene oxide or gamma radiation and supplied in double-seal envelopes
  • created to keep the drug uncontaminated and isolated from the external environment
  • with two pierceable septa, one upper and the other lower, located at the ends along the axis of the device
  • sized to accommodate up to 9 ml of liquid
  • with a hydrophobic membrane and micro filter for air ventilation at the time of filling
  • head to check the air tightness and the structural strength
  • pierceable multiple times without losing air tightness

Related products

MUSA 68Ga – Shielded Isolator for Gallium-68 Synthesis and Dispensing

The isolator has been designed to optimise the Gallium-68 processes (synthesis and dispensing) extracted from generator 68Ga/68Ge. It...
Learn more

MANUELA – Shielded Laminar Flow Hot Cell for Nuclear Medicine

MANUELA is a shielded cell for the manipulation of radio medicines, in particular, for the fractioning of positron...
Learn more

FEBO Series Syringe Dispensing System

FEBO Series Syringe Dispensing System are designed for safe and accurate fractionation of radiopharmaceuticals in syringes. The FEBO...
Learn more

CLIO Volumetric Dispenser for Radiopharmaceuticals

CLIO is a standalone automatic volumetric dispensing system compliant with cGMP guidelines for radiopharmaceuticals. The main purpose is...
Learn more

Sign up for your Comecer Account

Registration is for professionals that work with containment and Isolation Technologies and grants full access to our product data sheets and catalogues.
Comecer newsletter. Please select your categories of interest:
I have read and understood the information sheet pursuant to Art. 13 GDPR.
I express my consent to process my personal data for marketing purposes and the sending of promotional and informative material, including newsletters and commercial communications concerning Comecer products/services, as indicated in the section “Data processed and Purposes of processing” of the Privacy Policy published on the website.
I express my consent also for the processing of my personal data for profiling purposes and for the analysis of the preferences, interests and habits, as indicated in the section “Data processed and Purposes of processing” of the Privacy Policy published on the website.

Maggiori informazioni



Warning! The content in this page is available only in the following languages: Italian

I cookie necessari sono i cookie tecnici cioè quelli il cui utilizzo non richiede il consenso dell’utente.

Questi cookie sono essenziali per consentire di navigare in un sito web e utilizzarne tutte le funzionalità. Senza questi cookie, che sono assolutamente necessari, un sito web non potrebbe fornire alcuni servizi o funzioni e la navigazione non sarebbe agevole e facile come dovrebbe essere. Un cookie di questo tipo viene inoltre utilizzato per memorizzare la decisione di un utente sull’utilizzo di cookie sul sito web.

I cookie tecnici sono essenziali e non possono essere disabilitati utilizzando questa funzionalità.
In generale comunque i cookie possono essere disattivati completamente nel proprio browser in qualsiasi istante.



Warning! The content in this page is available only in the following languages: Italian

I cookie statistici vengono utilizzati per monitorare le performances del sito, per esempio per conoscere il numero di pagine visitate o il numero di utenti che hanno visualizzato una determinata sezione.

I cookie statistici utilizzati dal nostro sito si avvalgono di servizio di Google Analytics.

L’analisi di questi cookie genera dati statistici anonimi e aggregati senza riferimento alcuno all’identità dei navigatori del sito. Sono utili anche per valutare eventuali modifiche e miglioramenti da apportare al sito stesso.



Warning! The content in this page is available only in the following languages: Italian

I cookie di targeting sono cookie impostati da terze parti come YouTube, Facebook, Twitter.

Questi cookie tengono traccia del tuo comportamento come la riproduzione di video o quali tweet hai già visualizzato.

Se non viene dato il consenso a questi cookie, non sarà possibile guardare i video su questo sito web o utilizzare la funzionalità di condivisione sui social.

Questi cookie possono essere utilizzati dal fornitore di cookie per creare un profilo dei tuoi interessi e mostrarti pubblicità pertinenti su altri siti. Non memorizzano direttamente informazioni personali, ma si basano sull'identificazione univoca del browser e del dispositivo Internet.