PHAEDRA COMBO Series Synthesis and Dispensing Shielded Isolator

Phaedra Combo series is a family of shielded isolators specifically designed to combine, in a single system, a shielded housing for synthesis modules and a fractioning area in sterile conditions (Class A LAF), in compliance with the regulations cGMP; for this reason, they are also equipped with a Class B pre-chamber of materials input.

Usato in Radiofarmacia Per Calibrazione di dose Riempimento Sintesi R&D Radiochimica e Radiofarma Dispensazione
PHAEDRA-COMBO Synthesis and dispensing hot cell


  • Synthesis chamber air quality up to Class B
  • Dispensing chamber air quality Class A with laminar flow
  • Gloves pre-chamber air quality Class B
  • Waste compartment air quality Class B
  • Modular design and flexible configuration
  • Synthesis and dispensing in a single cell
  • Ideal for aseptic dispensing of vials or syringes in cGMP field
  • Ergonomic and responsive thanks to the combination of gloves for manipulation and tele-pliers
  • Extraction system for vials and syringes in transport shielded container equipped with pass-through dose calibrator
  • Compact solution, also suitable for small laboratories
  • Touch-screen operator panel
  • Tele-pliers with “QuickPlug” system for quick tight release
  • Dose calibrator (available in the 2 Ci or 20 Ci versions)
  • Waste compartment

Thanks to its characteristics it is possible to guarantee the radioprotection of the operator and the maximum effectiveness of the decontamination and cleaning procedures. The housing for the synthesis modules is hermetically sealed and shielded on each side, maintained in negative pressure for the production (with automatic modules) of the drug radio.
Thereafter the drug radio can be transferred, by means of an internal shielded conduit, into the main Class A chamber.
The main chamber is equipped with a telehandle that allows high-level handling operations in total safety, both with hand-held doors that guarantee the possibility of performing manual operations, always in compliance with radiation protection regulations. The telepinza is equipped with the “QuickPlug” system that allows its rapid extraction without loss of seal and classification, so that it can be quickly switched between the telepinza operations and the manual operations.
The working area of ​​the main chamber has been carefully designed to ensure excellent ergonomics during the use of the devices that can be installed (calibrator, dispenser, waste compartment and unloading system for bottles and syringes).

Main Features

  • Shielded and hinged front door of the main chamber equipped with glass and hand doors for manipulation.
  • Class A, 75 mm lead shielding on the entire work area
  • Dose calibrator compartment equipped with pneumatic system to move the vial in the well
  • Filtration system to generate laminar flow in the Class A chamber, made with ULPA U15 absolute filtering cartridge
  • Hinged front door of the material input chamber made of Plexiglas and equipped with glove flanges
  • Filtration system for Class B chambers with HEPA H14 absolute filtering cartridge
  • Technical cabinet to contain the control box for the synthesis module and any HPLC pump
  • Air outlet filtration system made with active carbon filtering cartridge
  • Chambers tightness ensured by inflatable gasket system, placed on the perimeter of the openings
  • Shielded chamber under constant negative or positive pressure (upon request)
  • 316L AISI stainless steel work chambers with Mirror-Bright internal surface finish, TIG continuous welds, and widely rounded corners
  • 304 AISI stainless steel front coverings, easy to decontaminate, separates the laboratory area (front) from the technical cabinet (rear)
  • 12” touch-screen operator panel to check and trace the critical parameters of the machine both in “at rest” or “in operation” mode.
  • Radio-fluid airtight shielded inlets in the synthesis and dispensing chambers
  • Airtight shielded capillary passage between the synthesis chamber and the dispensing chamber
  • Cable inlet through multi-diameter airtight system in the synthesis and dispensing chambers
  • Protected electric power supply socket in the synthesis and dispensing chambers controlled from the operator panel
  • Temperature and humidity sensor
  • Connection for DOP test (filter sealing test) for absolute filters in the synthesis and dispensing chambers
  • Semi-automatic Bubble Point Test can be installed, integrated with COMECER dispensers
  • Possibility of installing a Geiger-Muller probe to detect radioactivity inside the cell and door interlock management


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