ALCEO Solid Target Processing System

The series is a family of configurable machines based on various parameters such as:

  • the type of isotope
  • the specific radioisotopes to be produced
  • use of “disposable cassette”
  • the type of process chosen for the production of several radioisotopes:
    Mixed: several production processes are carried out from the same configuration
    Separated: each production process has its specific configuration).

The radioisotopes that can be produced are 64Cu, 89Zr, 124I, 123I and 68Ga.

Used in Radiopharma Production For R&D Radiochemistry and Radiopharma Synthesis
 
Alceo Solid Target Processing System
  • Modular Design
  • Halogen System (for 123I and 124I)
  • Metal System (for 64Cu, 89Zr and 68Ga)
  • Bi-directional Pneumatic Target Transfer  between cyclotron and hot cells
  • One Cyclotron port is required for both Systems
  • Irradiation Unit with Foil supported by  Water-cooled Hexagonal Grid
  • Independent Water and Helium Cooling
  • No operator contamination

The complete ALCEO configurations (ALCEO FULL) feature a single PTS (pneumatic transfer system) and Cooling System unit: the transport of the target to the corresponding module is performed via a target switch.
The radionuclides produced are available in a form suitable for radiopharmaceutical synthesis.
The integrated system allows all the operations to be carried out without the manual intervention of operators.
The ALCEO system is designed for the application of commercial cyclotrons with energy ranging between 5 and 30 Mev.

ALCEO HALOGEN 123I, 124I – Solid target processing system

It allows the irradiation of a Tellurium oxide deposit 124Te and 123Te to obtain the equivalent radionuclide 124I and 123I.

It consists of a module for the production of 124I and 123I (mixed process) and one single PTS.

ALCEO SYSTEM Halogen

TGT 124I – Target Shuttle

The target is the component which is directly irradiated by the cyclotron beam: it is an enriched metal isotope (123Te and 124Te) which produces the positron emitter (123I and 124I) after the bombardment.

PTS – Irradiation unit

The irradiation unit is directly connected to the cyclotron and guarantees the correct positioning of the target in front of the beam port. Target positioning is fully automated. The unit is connected to its own “water and helium cooling system”. The cooling system is connected to the cyclotron cold water and helium circuit, as a normal liquid target.

EVP – Iodine Evaporation/Purification unit

The unit can be placed inside a hot cell and must be connected to the PTS unit with the target transfer tube. The EVP module contains the necessary components for the following operations:

  • automatic transfer of the target shuttles between the hot cell and the cyclotron
  • plating of the target (tellurium dioxide) on the target shuttle
  • evaporation of the iodine radioisotope from the irradiated target.

The purification task makes use of a “disposable cassette”, in order to avoid the module contamination. Comecer supplies the cassette, while the preparation of the required synthesis reagents is the customer’s responsibility.

ALCEO METAL 64Cu, 89Zr AND 68Ga – Solid target processing system

It consists of one single PTS and two modules (a Dissolution/Transfer unit and a Purification unit) for the production of metal radioisotopes. The Dissolution/Transfer unit can be provided with several accessories such as the setup for Ni Plating and Cu Dissolution; Zn Plating and Ga Dissolution, Zr Dissolution. The modular configuration allows the simple upgrade for the production of the other metal radioisotopes (64Cu, 89Zr, 68Ga). In the fully accessorised configuration, it allows the irradiation of:

  • a Nickel layer (plating) 64Ni aimed at obtaining radionuclide 64Cu
  • a Yttrium natural foil 89Y aimed at obtaining radionuclide 89Zr
  • a Zinc layer (plating) 68Zn aimed at obtaining radionuclide 68Ga

ALCEO Metal

Metal Target Shuttle

The Alceo Metal target shuttle allows the automatic positioning of the metal isotope in front of the cyclotron beam.

PTS – Irradiation unit

The irradiation unit is directly connected to the cyclotron and guarantees the correct positioning of the target in front of the beam port. Target positioning is fully automated. The unit is connected to its own “water and helium cooling system”.

EDS – Electrochemical/Dissolution/Transfer/Storage unit

It can be placed inside a hot cell which is connected to the cyclotron by a flexible tube for the target transfer. It is a pneumatic system that automatically carries out the following operations:

  • automatic transfer of the targets between the hot cell and the cyclotron
  • electrochemical deposition of the enriched metal isotope on the shuttle platinum well (specific accessory)
  • dissolution of the irradiated isotope (specific accessory)
  • storage of target shuttles.

TADDEO-PRF – Purification module

It can be placed inside a hot cell and must be connected to the Dissolution/Transfer unit by capillary lines. The Purification module contains the necessary components for the purification by ion chromatography of the produced radioisotope (64Cu, 89Zr, 68Ga). The module is based on disposable cassettes.

ALCEO RETROFIT – 64Cu, 89Zr and 68Ga production for laboratories without solid target presetting

ALCEO METAL RETROFIT is the best solution for a pre-existing laboratory, where hot cells and trenches for capillary passage do not possess the requirements for proper installation of the ALCEO METAL.

ALCEO METAL RETROFIT is based on ‘accessories’ as the standard Alceo Metal, but the dissolution and purification phases are separated in distinct areas. In this configuration, connection between the two areas consists of a single fluid transfer capillary and not of a complex pneumatic transfer system of the target using corrugated pipe. In the fully accessorised configuration, it allows the production of 64Cu, 89Zr, 68Ga.

ALCEO Metal Retrofit

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