ValueCell FILL
Semi-automatic and refrigerated bag aseptic filling system for Cell & Gene applications

ValueCell FILL is a new semi-automatic COMECER filling system for Cell & Gene therapy fields. It is easy to use, modular and versatile.

ValueCell FILL is a simple and straightforward technology for assisting customers during their downstream aseptic bag filling operations. ValueCell FILL is one of the COMECER’s offerings to support new filling needs in the fields of Cell & Gene therapies and related areas (Viral filling, Media filling), with options for cryogenic filling.

Unique Features

  • Bag dispensing is usually performed in a one-by-one filling fashion. In ValueCell FILL the receiving bags are assembled together in a Single-Use Set, sharing a common pre-sterilized manifold.
  • Bag dispensing usually needs to be carried out in grade A, as the filling is an open activity. In ValueCell FILL the filling is performed under closed conditions, so the machine is suitable to be used lower room classifications such as Grade C environments.
  • Air removal from the filling line through an additional bag collecting the air in the tubes while priming the line.
  • Product saving by reverse pumping at the end of the filling process, to avoid discarding of vital product left over in the lines.
  • Illuminate™ MI: IIoT manufacturing intelligence platform and factory-floor management.

A new tool for Cell & Gene Therapy applications

The primary goal of ValueCell FILL is to dispense production bulks (held in a suitable source bag) into a series of final or intermediate bags.

Main Components

ValueCell FILL, new semi-automatic COMECER filling system for Cell & Gene therapy fields, has a modular structure where three main components can be identified:

ValueCell FILL - Filling system for Cell & Gene


Optional features

A suitable mixing system can be added in the storage compartment, to allow an initial formulation of the product solution to be dispensed, e.g., adding dilution or cryopreserving component before dispensing in the final bags.

Where required, ValueCell FILL can be equipped with a paddle mixer, in order to keep the density of the dispensed solution as constant as possible during the dispensing process.

Specific customer needs can be investigated and Comecer can provide a personalized version of ValueCell FILL.


Bag formats: a certain degree of customization is available to meet specific customer needs. To know more about available formats and potential new applications, you should get in contact with our Sales Team.

The filling module can be adapted, in terms number of bags for filling. Currently available options include 5, 10 and 15 dispensing bags. One bag is always kept as reservoir for the air in the tubing system (it can be used as a QC sample too) giving customers flexibility over several features of different applications.

Closing system: the possibility to seal and cut the bags using thermal welding is currently under investigation and will be available in the future as a standard option.

ValueCell FILL - new semi-automatic filling system for Cell & Gene therapy fields + illuminate

Release the full potential of ValueCell FILL with Illuminate™ Manufacturing Intelligence

Use real-time machine performance data to pinpoint where to focus efforts to reduce downtime, maximize line throughput, improve product quality, and make sustainable production improvements. Learn more »

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ValueCell FILL - new semi-automatic filling system for Cell & Gene therapy fields