The Ioflupane I-123 radiopharmaceutical production line is a highly automated plant for dispensing batches of 500 vials at a speed of 360 vials per hour.
The plant is composed of shielded isolators in which transport, aseptic filling, visual inspection and labelling systems are integrated. The radiopharmaceutical formulation part integrates devices to perform the formulation and labelling process of the 123I in a fully automatic way. The system involves the use of 4 HPLC, disposable pipes, valves and peristaltic pumps. The aseptic dispensing part meets all the requirements of sterile pharma production lines and uses a continuous feed system where vial de-capping, filling with weight feedback, capping and crimping operations take place. The vial is then buffered through a Cartesian robotic system to allow a semi-automatic visual inspection over the entire batch to verify the absence of particulate matter and aesthetic defects. Finally, the vials leaving the inspection area are labelled and placed in the transport container.