Isolator Technologies for Primary Pharmaceutical Production

Our Isolator Technologies for Primary Pharmaceutical Production cover the widest range of processes, from early API or excipient synthesis to final formulations. In this field, we handle all the various processes, from R&D to manufacturing, including main and ancillary equipment.

From Primary chemical industry manufacturing and R&D, to high-potent API dispensing and charging in reactor from the chemical synthesis, through the process phases to the final primary packaging.

Solving customer problems requires teamwork

  • Weigh and dispense highly potent active powders, securely and ergonomically, with attention to operator safety.
  • Fill drums or vials with sterile powder or liquid in a completely automated manner while maintaining product sterility.
  • Manipulate cell cultures under aseptic conditions
  • Perform sterility testing on products for a safe release to the market.
  • Prepare hospital oncology drugs ensuring both operator and product safety.

Specific solutions for all R&D chemical synthesis and manufacturing processes that match customer requirements, such as equipment integration, ATEX environment classification and lowest OEL (Operator Exposure Limit).

Customized solutions

Our Isolators can be customized for perfect integration of ancillary and process equipment to guarantee class 2 leakage test, ATEX 3GD or more internal and external classification, complete safety and ergonomic design for operator safety.

Configurations

R&D or pilot scale application: multistage chambers isolator with kilo-labo reactor, vacuum tray dryer and laboratory scale integration.
Manufacturing process isolator application: dispensing and sampling, reactor loading with direct connection to the reactor flange, filter dryer powder handling, milling discharge, sieving operation, micronization with integrated micronizer and packaging vacuum system.

PAPI

Potent API Processing Isolator

API Processing Pharma Dispensing · Containment
Comecer isolators for containment requirements are conceived for pharmaceutical companies who require high-level protection during potent API processing.
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Dispensing Isolator

Isolator for dispensing process

API Processing Pharma Dispensing · Containment
The isolator is designed for dispensing activities.
The dispensing isolator works at negative pressure compared to the laboratory to protect the operator.
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Production Isolator

Isolator for production process

API Processing Pharma Dispensing · Containment
The production isolator is designed for powder preparation and weighing activities. The isolator works at negative pressure compared to the laboratory to protect the operator.
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MD&WI

Modular Dispensing & Weighing Isolator

API Processing Pharma Dispensing · Containment
MD&WI Modular Dispensing & Weighing Isolator is conceived for pharmaceutical companies who require high containment level during manipulations of potentially dangerous products.
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HAPI Isolators

Isolators for safe HAPI (Highly Active Product Ingredients) transfer and dispensing

API Processing Pharma Containment
Isolators are designed to ensure suitable safety during transfer and dispensing of HAPI (Highly Active Product Ingredients).
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Dispensing and Weighing Isolator

Isolator for weighing and dispensing operations

API Processing Pharma Containment
The isolator was designed to permit the dispensing and weighing activities of micronized highly potent substances (progesterone OEL 0,01 mg/m3 ).
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ATEX Isolator

Isolator with ATEX compliant chamber for dispensing procedure

API Processing Pharma Containment
The ATEX isolator is designed to carry out weighing and powder transfer procedures (API) in complete safety. The ATEX isolator consists of a chamber equipped with connections for scales and cable runs, with a front wall in glass which can be opened completely. The chamber is also equipped with two spray balls and two spray guns for perfect cleaning.
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Dispensing Isolator

Glove box system

API Processing Pharma Containment
The purpose of this isolator is to ensure the operator's safety giving the maximum protection during all handling operations, ensuring the separation between the external and the internal glovebox environment. The operator works  while standing and is completely isolated from the substance being manipulated.
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Dispensing & Milling

Isolator for Dispensing & Milling

API Processing Pharma Containment
The isolator is composed of two glove box  chambers. The first is a prechamber for material inlet while the second is the central chamber for sieving, mixing and weighing. This second chamber  incorporates  a  mill placed on a special trolley equipped with adjustable steel wheels.
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Isolator for washing procedure

Isolator for washing procedures

API Processing Pharma Containment
This isolator permits the "manual" cleaning of machine parts ensuring complete isolation of the internal environment.
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Isolator for Compact Mixer-Granulator-Dryer

API Processing Pharma Containment
  • Glovebox chamber with negative pressure with respect to the laboratory environment
  • Fully PLC controlled (single PLC for isolator & mixer-granulator-dryer)
  • Top-down turbulent air flow
  • Glovebox pre-chamber for inlet and outlet procedures
  • Integrated CIP (clean in place)
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